I’d HIGHLY recommend going to check out Daryll’s Advocate, a syndicate-worthy comic strip done by a fellow forumer.
When I say “syndicate-worthy,” I’m not kidding. The art is top notch, and the writing and concept is reminiscient of Watterson. He’s doing it as a webcomic at the moment because: 1) it allows him to get the comic public and start getting support for it, and 2) it can act as an online portfolio for syndicate submission.
Go check it out. Oh, and be sure to check the portfolio page, too… some great stuff in there.